PolyOrthoesters form a very important class of bioresorbable polymers. We call them Orthomer™. PolyOrthoesters are of growing interest for controlled drug and gene delivery applications. They tend to degrade through surface erosion unlike most polyesters such as PLA and PLGA. The polymers are stable at alkaline and neutral conditions, but rapidly hydrolyze at acidic conditions.
PolyOrthoesters are normally low in molecular weight making them interesting for injectable formulations. However, solid polymers and with larger molecular weight can be made as well.
We have years of experience in synthesizing PolyOrthoesters with variations in composition and molecular weights. The basic monomer or building block is always DETOSU for the orthoester part. Popular comonomers are TEG, PEG and aliphatic or cyclic diols either or not combined with lactic acid or glycolic acid. The latter acids will accelerate the hydrolysis rate of the so obtained orthoester copolymers.
We developed an unique synthesis process that allows effective up-scaling both in terms of volume as well as quality (cGMP).
We fully customize Orthomer™ orthoester copolymers to your requirements.
Orthomer™ is a registered trademark of PolyVation.